Ceruloplasmin 0.1 mg Ceruloplasmin 0.05 mg

Source: Chicken

 Purity: Immunoaffinity Purified

 Clonality: Polyclonal

 Crossreactivity: Human

 Format: Phosphate-Buffered Saline. No preservatives added.

 Storage: 4 degree C for short term (weeks) and -20 degree C for long term. Avoid frequent freeze and thaw.

 Stability: 6-12 months at -20 degree C.

 Shipping: Products may be shipped on ice pack or dry ice. 
 
 CP ANTIBODY TARGET DESCRIPTION:
Synonym Names for CP antibody: CP; CP-2; EC 1.16.3.1; Ferroxidase; Ceruloplasmin (ferroxidase)

Function: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing iron(II) to iron(III) without releasing radical oxygen species. It is involved in iron transport across the cell membrane.

Catalytic Activity: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Cofactor: Binds 6 copper ions per monomer.

Subcellular Location: Secreted protein.

Tissue Specificity: Expressed by the liver and secreted in plasma.

Disease: Defects in CP are the cause of aceruloplasminemia [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.

Disease: Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.

Similarity: Belongs to the multicopper oxidase family.

Similarity: Contains 3 F5/8 type A domains.

Similarity: Contains 6 plastocyanin-like domains.

Summary: Ceruloplasmin is a plasma metalloprotein that that binds most of the copper in plasma. Human ceruloplasmin is composed of a single polypeptide chain. Ceruloplasmin deficiency leads to iron accumulation and cuases damages to a varieties of tissues and organs.

Ceruloplasmin reacts with human.

OMIM: 117700; gene. [NCBI / EBI]
604290; phenotype. [NCBI / EBI]

Pathways:
KEGG pathway: Porphyrin and chlorophyll metabolism 00860

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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more. 
 
 APPLICATIONS for CP ANTIBODY:
 ELISA, WB: Tested
 ICC, IHC: Not Tested